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Joint or muscle pain. While most patients will not have an issue with gastrointestinal side effects they are possible due to the effects of naltrexone on intestinal opioid receptors. Pin On Thyroid Adrenal Information Low dose naltrexone was terminated owing to side effects in 2074 patients 270. . Drowsiness extreme dizziness or weakness irregular fast or slow or shallow breathing pale or blue lips fingernails or skin pinpoint pupils relaxed and calm slow heartbeat or breathing seizures sleepiness trouble breathing or cold clammy skin. Nervousness Sleeping troubles Muscle or joint pain. Most of such side effects tend to be mild and disappear over time. From the more common symptoms such as nausea headaches stomach or muscle pain and unusual feeling of tiredness to more serious health concerns such as liver damage tenderness and redness users need to know about the. Symptoms of an opioid overdose include. By well conducted studies one is sp...